Merkel Cell Carcinoma Histologic Features

Merkel cell carcinoma MCC is an aggressive cutaneous neuroendocrine carcinoma. Most MCC are usually positive to cytokeratin 20 CK20 stain as well as may show some neuroendocrine differentiation expressing either neuron specific enolase.

Merkel Cell Carcinoma A Review And Update On Current Concepts Diagnostic Histopathology

In addition to the known prognostic value of tumor stage 3 histologic features were identified to have prognostic significance.

Merkel cell carcinoma histologic features. MCC is a fatal disease and patients have a poor chance of survival. Merkel cell carcinoma MCC of the skin is an aggressive but rare malignant neuroendocrine tumor. A 71-year-old man was referred to our.

Merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. In addition to the known prognostic value of tumor stage 3 histologic features were identified to have prognostic significance. This tumor has a high rate of recurrence and metastasis the main histopathological differential diagnosis is cell lung carcinoma SCLC.

The first description of Merkel cell carcinoma MCC was published in 1972 when Toker described five patients with unusual skin tumours characterized by histologically anastomosing trabeculae and cell nests1 The term Merkel cell carcinoma was coined by DeWoolf-Peters in 1980 and today remains themost accepted terminology2 Case Report. In a retrospective review of the tumor histology and clinical outcome data median followup 51 months. Merkel cell carcinoma MCC is an unusual primary neuroendocrine carcinoma of the skin.

Our purpose was to determine whether there were clinical or histologic features of MCC that predict its biologic behaviorMethods. House MDa Fred Fedok MDb Mary E. Tumor thickness depth of tumor invasion the presence of LVI and tumor.

Moreover MCC lacks distinguishing clinical features and thus by the time the diagnosis is made the tumour usually have metastasized. Histologic features and prognosis. Helm MDa c Hershey Pennsylvania We describe a patient with malignantmelanoma thatresembled a Merkelcell carcinoma.

Range 3-224 months of 156 patients with a diagnosis of MCC the following. MCC mainly affects sun-exposed areas of elderly persons. There have been few large studies of the biologic behavior of MCC.

Tumor thickness depth of tumor invasion the presence of LVI and tumor growth pattern. Histologic features that favor DTE are architectural symmetry horn cysts with calcifications narrow cellular aggregates giant cell reactions and follicularsebaceousinfundibular differentiation Table. Incidence of MCC continues to rise and risk factors include advanced age pale skin chronic sun exposure and.

Regardless of histopathologic type Merkel cell carcinoma is usually composed of small round-to-polygonal basaloid cells with inconspicuous nucleoli and open chromatin with peripheral. Andea AA Coit DG Amin B et al. One of the histologic features of BCC either a mucinous stroma or stromal artifactual retraction was identified in all MCCs.

Tumor thickness tumor size greatest dimension of the tumor microanatomic compartment involved by tumor dermis andor subcutis andor deeper tumor growth pattern nodular. Merkel cell carcinoma MCC is a relatively rare potentiallyaggressivecutaneousmalignancywitha highincidenceoflocalrecurrenceandregionaland distant metastasis. Merkel cell carcinoma MCC is an uncommon malignancy of the skin and has a high rate of recurrence and metastasis.

The majority of patients with MCC70presentwithdiseaseclinicallylocalized to the skin American Joint Committee on Cancer stage I or II 25 present with palpable regional. Merkel cell carcinoma MCC is an uncommon malignancy of the skin and has a high rate of recurrence and metastasis. 18798233 Paulson KG Iyer JG Tegeder AR et al.

There have been few large studies of the biologic behavior of MCC. A mucinous stroma was found in 28 MCCs 93 stromal artifactual retraction in 27 90 mucin-containing gland-like spaces within tumor nests in 8 27 focal peripheral palisading in 8 27 epidermal involvement in 3 10 and dystrophic calcification in 1. Journal of the American Academy of DERMATOLOGY VOLUME 31 NUMBER 5 PART 2 NOVEMBER 1994 Malignant melanoma with clinical and histologic features of Merkel cell carcinoma Nancy S.

Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8 lymphocyte invasion as an independent predictor of survival. Maloney MDa and Klaus F. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions.

We reviewed 132 cases of MCC. Our purpose was to determine whether there were clinical or histologic features of MCC that predict its biologic behavior. In a retrospective review of the tumor histology and clinical outcome data median follow-up 51 months.

J Clin Oncol. Range 3224 months of 156 patients with a diagnosis of MCC the following histologic features were evaluated.

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